The epidermal growth factor family profile

    The epidermal growth factor family (epidermal growthfac-tor family) is a group of and epidermal growth factor (EGF epidermal growthfactor) structure and the biological function of close glycoprotein, it consists of EGF, transformation growth factor (transform-ing growthfactor, TGF), heparin combination EGF sample growth factor

  (heparin-binding EGF-likegrowth factor,HB-EGF),gender regulatory protein(amphiregulin,AR),cellularregulation element(betacellulin,BTC),epiregulin,NDFs (neudifferentiationfactors), a growth factor. These growth factor has high sequence homology, all from the molecular weight of the larger across a cell membrane precursor protein, the mature molecules in cell membranes are outside the protease cracking that area into. These EGF related proteins all contains six homocysteine residual base of conservative district, this area homocysteine matching form 3 stable chain disulfide key, EGF related proteins form specific space structure has an important role, but also related with protein receptors EGF of position.

    EGF receptor (EGFR) family including ErbB1 ErbB2, (HER2), ErbB3 (HER3) and ErbB4 (HER4) four receptor tyrosine kinase. EGF related proteins has many physiological functions, they are not only the material and transport, sugar metabolism, cell proliferation and extracellular matrix synthesis and fibroblasts migration of such relevant, and in mammals the adjustment of the reproductive process also plays an important role.

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