lecular structure of the epidermal growth factor (EGF)

    EGF is by 53 amino acid residues of a peptide, molecular weight for 6045 D. The earliest EGF is 1962 years from mouse contents extract to extract a thermal stability of material, since it has induced eyelids open and mice early early out the role of long teeth and was named the epidermal growth factor. EGF is through the cell membrane and the epidermal growth factor receptor (EGFR) combined with and play their role. EGFR is a exists in the surface of cells across the membrane protein molecules multi-function, distribution is very wide, the molecular weight for 170 kD, by 1186 amino acid residues form, as the cancer gene c-erbB1 encoded. The gene in mice in the article 11 and article 7 chromosome chromosome. The structure is divided into three areas: to the film and identify and combination of EGF, is located in the area by the middle of the cell membrane across a cell membrane and with tyrosine kinase activity area of the cytoplasm of the carboxyl area.

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