Epidermal growth factor (EGF) found

      In 1962, Dr. Cohen accidentally discovered in an experiment of epidermal growth factor (EGF), it is a widely present in the small molecule peptide or other animals, a very low concentration, can strongly stimulate cell growth, inhibit the aging gene appears, slow down the aging epidermal cells. Combining with its receptor play a role.

      Epidermal growth factor receptor (EGFR) is a tyrosine kinase activity of the membrane surface receptors, intracellular District 3 sub-region is to play the key parts of the tyrosine kinase-mediated signal transduction. epidermal growth factor receptor and the erbB receptors can form homologous and heterologous variety of dimers, six kinds of different combinations of ligands of the dimer and epidermal growth factor receptor may be different cell extracellular stimuli incoming cell epidermal growth factor can activate multiple downstream signal path, resulting in a variety of biological effects of activation of ras-raf-MEK-erk/MAPK ways and proliferation, P13K-PKC-IKK pathway and cell migration enhancements.